Intramolecular palladium mediated I-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines

Intramolecular palladium mediated I-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines

The Pd-mediated I-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines 4 and 14b led to the formation of five- and six-membered heterocycles 5 and 17 in high yields.

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Veröffentlicht in:Tetrahedron letters 2013-12, Vol.54 (49), p.6716-6718
Hauptverfasser: Al-Shuhaib, Zainab, Bockemeier, Henning, Coghlan, Lawrence, Dorksen, Elina, Jones, Iestyn, Murphy, Patrick, Nash, Robert, Page, James
Format: Artikel
Sprache:eng
Schlagworte:
Formations
Guanidines
Palladium
Tetrahedrons
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Beschreibung
Zusammenfassung:The Pd-mediated I-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines 4 and 14b led to the formation of five- and six-membered heterocycles 5 and 17 in high yields.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2013.09.093