Synthesis and properties of chiral internally branched PAMAM-dendrimers

Synthesis and properties of chiral internally branched PAMAM-dendrimers

Improved synthetic methodology for the synthesis of internally branched chiral poly(amidoamine) (PAMAM) dendrons and dendrimers has been developed and the compounds have been characterized by NMR spectroscopy, IR spectroscopy, and optical rotation measurements. The dendrons and dendrimers show incre...

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Veröffentlicht in:Tetrahedron 2015-02, Vol.71 (7), p.1109-1116
Hauptverfasser: Petersen, Johannes F., Tortzen, Christian G., Pittelkow, Michael, Christensen, Jørn B.
Format: Artikel
Sprache:eng
Schlagworte:
Amide coupling
Branched
Convergent synthesis
Dendrimer
Dendrimers
Hydrogen bonding
Infrared radiation
Internal branching
NMR spectroscopy
Optical activity
Optical properties
Optical rotation
Synthesis (chemistry)
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Zusammenfassung:Improved synthetic methodology for the synthesis of internally branched chiral poly(amidoamine) (PAMAM) dendrons and dendrimers has been developed and the compounds have been characterized by NMR spectroscopy, IR spectroscopy, and optical rotation measurements. The dendrons and dendrimers show increased degree of internal hydrogen bonding upon increasing generation and the presence of different types of amide-protons in the compounds is indicative of the existence of a tertiary structure in these PAMAM-dendrimers. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.12.080