Dual-sugar Nanogel Comprising β-1,3-Glucan and Cholesterol-bearing Dextran for Protein Delivery Targeting Antigen Presenting Cells

Dual-sugar Nanogel Comprising β-1,3-Glucan and Cholesterol-bearing Dextran for Protein Delivery Targeting Antigen Presenting Cells

A dual-sugar nanogel containing proteins was prepared by a simple mixing of schizophyllan (SPG) in NaOH (0.25 M), cholesterol-hydrophobized dextran (CH-CDex) in NaH2PO4 solution, and BSA. It was found that this nanogel was specifically taken up by SPG receptors present on antigen presenting cells.

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Bibliographische Detailangaben
Veröffentlicht in:Chemistry letters 2014-05, Vol.43 (5), p.652-654
Hauptverfasser: Maegawa, Yoshiya, Mochizuki, Shinichi, Sanada, Yusuke, Akiyoshi, Kazunari, Sakurai, Kazuo
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Dextrans
Drug Delivery
Nanostructure
Proteins
Receptors
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Beschreibung
Zusammenfassung:A dual-sugar nanogel containing proteins was prepared by a simple mixing of schizophyllan (SPG) in NaOH (0.25 M), cholesterol-hydrophobized dextran (CH-CDex) in NaH2PO4 solution, and BSA. It was found that this nanogel was specifically taken up by SPG receptors present on antigen presenting cells.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.131201