A facile, one-pot procedure for the formation of benzimidazoles from esters using DABAL-Me sub(3), an air stable source of AlMe sub(3)

A facile, one-pot procedure for the formation of benzimidazoles from esters using DABAL-Me sub(3), an air stable source of AlMe sub(3)

A convenient, single-step, efficient synthesis of benzimidazoles from esters and diamines is reported. The methodology uses an air stable form of trimethylaluminum referred to as DABAL-Me sub(3) and is compatible with a wide range of functional groups, including acid-sensitive protecting groups.

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Veröffentlicht in:Tetrahedron letters 2014-08, Vol.55 (35), p.4853-4855
Hauptverfasser: Pinder, Joanne L, Davis, Rebecca E, Charrier, Jean-Damien
Format: Artikel
Sprache:eng
Schlagworte:
Compatibility
Diamines
Esters
Formations
Functional groups
Methodology
Synthesis
Tetrahedrons
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Beschreibung
Zusammenfassung:A convenient, single-step, efficient synthesis of benzimidazoles from esters and diamines is reported. The methodology uses an air stable form of trimethylaluminum referred to as DABAL-Me sub(3) and is compatible with a wide range of functional groups, including acid-sensitive protecting groups.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2014.06.026