Rhodium(III)-catalyzed synthesis of indoles from 1-alkylidene-2-arylhydrazines and alkynes via C–H and N–N bond cleavages

1-Alkylidene-2-arylhydrazines undergo annulative coupling with internal alkynes in the presence of a rhodium(III) catalyst and a copper(II) salt. The reaction proceeds through cleavage of the C–H and N–N bonds of hydrazines to afford 1,2,3-trisubstituted indole derivatives.

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Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2014-05, Vol.55 (22), p.3302-3304
Hauptverfasser:	Matsuda, Takanori, Tomaru, Yuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyne Alkynes Annulation Bonding Cleavage C–H bond functionalization Derivatives Hydrazine Hydrazines Indole Indoles Joining Rhodium Tetrahedrons
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Beschreibung
Zusammenfassung:	1-Alkylidene-2-arylhydrazines undergo annulative coupling with internal alkynes in the presence of a rhodium(III) catalyst and a copper(II) salt. The reaction proceeds through cleavage of the C–H and N–N bonds of hydrazines to afford 1,2,3-trisubstituted indole derivatives.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2014.04.016