Chiral initiator-induces self-disproportionation of enantiomers via achiral chromatography: application to enantiomer separation of racemate

Chiral initiator-induces self-disproportionation of enantiomers via achiral chromatography: application to enantiomer separation of racemate

We report here the theoretical design and proof of principle of the first example of a conceptually new approach for the preparation of enantiomerically pure compounds from the racemates by chiral initiator-induced Self-Disproportionation of Enantiomers (SDE) via achiral chromatography.

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Veröffentlicht in:Tetrahedron letters 2013-09, Vol.54 (38), p.5220-5223
Hauptverfasser: Tateishi, Kaori, Tsukagoshi, Shiori, Nakamura, Tsuyoshi, Watanabe, Shotaro, Soloshonok, Vadim A., Kitagawa, Osamu
Format: Artikel
Sprache:eng
Schlagworte:
Association
Chromatography
Disproportionation
Enantiomers
Optical resolution
Proving
Separation
Tetrahedrons
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Beschreibung
Zusammenfassung:We report here the theoretical design and proof of principle of the first example of a conceptually new approach for the preparation of enantiomerically pure compounds from the racemates by chiral initiator-induced Self-Disproportionation of Enantiomers (SDE) via achiral chromatography.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.07.061