A short synthesis of (2S,3S)-3-hydroxypipecolic acid

A convenient synthesis of (2S,3S)-3-hydroxypipecolic acid starting from cheap and abundant l-(+)-tartaric acid has been achieved. The strategy employs selective ester reduction and reductive lactamization as key steps.

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Veröffentlicht in:Tetrahedron letters 2013-09, Vol.54 (36), p.4851-4853
Hauptverfasser: Chavan, Subhash P., Harale, Kishor R., Pawar, Kailash P.
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container_title Tetrahedron letters
container_volume 54
creator Chavan, Subhash P.
Harale, Kishor R.
Pawar, Kailash P.
description A convenient synthesis of (2S,3S)-3-hydroxypipecolic acid starting from cheap and abundant l-(+)-tartaric acid has been achieved. The strategy employs selective ester reduction and reductive lactamization as key steps.
doi_str_mv 10.1016/j.tetlet.2013.06.111
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source Elsevier ScienceDirect Journals
subjects Esters
Reduction
Reductive lactamization
Selective deprotection
Strategy
Synthesis (chemistry)
Tetrahedrons
Wittig reaction
title A short synthesis of (2S,3S)-3-hydroxypipecolic acid
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