A short synthesis of (2S,3S)-3-hydroxypipecolic acid

A short synthesis of (2S,3S)-3-hydroxypipecolic acid

A convenient synthesis of (2S,3S)-3-hydroxypipecolic acid starting from cheap and abundant l-(+)-tartaric acid has been achieved. The strategy employs selective ester reduction and reductive lactamization as key steps.

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2013-09, Vol.54 (36), p.4851-4853
Hauptverfasser: Chavan, Subhash P., Harale, Kishor R., Pawar, Kailash P.
Format: Artikel
Sprache:eng
Schlagworte:
Esters
Reduction
Reductive lactamization
Selective deprotection
Strategy
Synthesis (chemistry)
Tetrahedrons
Wittig reaction
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Beschreibung
Zusammenfassung:A convenient synthesis of (2S,3S)-3-hydroxypipecolic acid starting from cheap and abundant l-(+)-tartaric acid has been achieved. The strategy employs selective ester reduction and reductive lactamization as key steps.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.06.111