Regio-selective synthesis of 1,2-aminoalcohols from epoxides and chlorohydrins

Regio-selective synthesis of 1,2-aminoalcohols from epoxides and chlorohydrins

A simple and efficient procedure for the regio-selective synthesis of 1,2-aminoalcohols from terminal epoxides and chlorohydrins by using NaHMDS as the source of amine is reported. The wider scope and utility of this method is demonstrated.

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Veröffentlicht in:Tetrahedron letters 2012-10, Vol.53 (43), p.5739-5741
Hauptverfasser: Murugan, Andiappan, Kadambar, Vasantha Krishna, Bachu, Sreekanth, Rajashekher Reddy, M., Torlikonda, Venkatarao, Manjunatha, Sulur G., Ramasubramanian, Sridharan, Nambiar, Sudhir, Howell, Gareth P., Withnall, Jane
Format: Artikel
Sprache:eng
Schlagworte:
1,2-Aminoalcohol
Amines
Chlorohydrin
Epoxide
Epoxide opening
NaHMDS
Regio-selective
Synthesis (chemistry)
Terminals
Tetrahedrons
Utilities
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Beschreibung
Zusammenfassung:A simple and efficient procedure for the regio-selective synthesis of 1,2-aminoalcohols from terminal epoxides and chlorohydrins by using NaHMDS as the source of amine is reported. The wider scope and utility of this method is demonstrated.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.08.013