Palladium-catalyzed direct oxidative ortho-acylation of anilides with toluene derivatives

Palladium-catalyzed direct oxidative ortho-acylation of anilides with toluene derivatives

Direct oxidative ortho-acylation reaction of anilides with toluene derivatives in the presence of palladium acetate using tert-butyl hydroperoxide as an oxidant was developed. A broad range of diaryl ketones was obtained in good to excellent yields (up to 95%). The plausible mechanism was also propo...

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Veröffentlicht in:Tetrahedron letters 2013-03, Vol.54 (10), p.1205-1207
Hauptverfasser: Weng, Jianquan, Yu, Zhiqin, Liu, Xinghai, Zhang, Guofu
Format: Artikel
Sprache:eng
Schlagworte:
Acetates
Acylation
Anilide
Cross-coupling
Derivatives
Ketones
Oxidants
Oxidizing agents
Palladium
Palladium-catalyzed
Tetrahedrons
Toluene
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Zusammenfassung:Direct oxidative ortho-acylation reaction of anilides with toluene derivatives in the presence of palladium acetate using tert-butyl hydroperoxide as an oxidant was developed. A broad range of diaryl ketones was obtained in good to excellent yields (up to 95%). The plausible mechanism was also proposed.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.12.059