A new and facile tetrachlorosilane-promoted one-pot condensation for the synthesis of a novel series of tetracyclic 1,5-thiazepines

A new and facile tetrachlorosilane-promoted one-pot condensation for the synthesis of a novel series of tetracyclic 1,5-thiazepines

A new and facile approach for the one-pot synthesis of a novel series of tetracyclic 1,5-thiazepines is described. The reaction occurs through cyclocondensation of fused cyclic ketones, aromatic aldehydes, and 2-aminothiophenol using tetrachlorosilane as a promoter in methylene chloride at ambient t...

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Veröffentlicht in:Tetrahedron letters 2014-10, Vol.55 (44), p.6039-6041
Hauptverfasser: Khatab, Tamer K., El-Bayouki, Khairy A.M., Basyouni, Wahid M.
Format: Artikel
Sprache:eng
Schlagworte:
1,5-Benzothiazepine
Aldehydes
Ambient temperature
Condensing
Ketones
Methylene chloride
One-pot synthesis
Synthesis (chemistry)
Tetrachlorosilane
Tetracyclic
Tetrahedrons
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Zusammenfassung:A new and facile approach for the one-pot synthesis of a novel series of tetracyclic 1,5-thiazepines is described. The reaction occurs through cyclocondensation of fused cyclic ketones, aromatic aldehydes, and 2-aminothiophenol using tetrachlorosilane as a promoter in methylene chloride at ambient temperature.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.09.006