A rapid, chromatography-free route to substituted acridine–isoalloxazine conjugates under microwave irradiation

A rapid, chromatography-free route to substituted acridine–isoalloxazine conjugates under microwave irradiation

Microwave irradiation was applied to a sequence of condensation reactions from readily available 9-chloroacridines to provide a range of novel acridine–isoalloxazine conjugates. The combination of these two moieties, both of biological interest, was achieved by a chromatography-free route.

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Veröffentlicht in:Tetrahedron letters 2014-05, Vol.55 (22), p.3308-3311
Hauptverfasser: Johns, Stephen C., Crouch, Laurie L.E., Grieve, Stephen, Maloney, Holly L., Peczkowski, Gary R., Jones, Allison E., Sharp, Duncan, Smith, Robert B.
Format: Artikel
Sprache:eng
Schlagworte:
Acridine
Biological
Chromatography
Condensing
Conjugates
Flavin
Irradiation
Isoalloxazine
Microwave
Microwaves
Tetrahedrons
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Zusammenfassung:Microwave irradiation was applied to a sequence of condensation reactions from readily available 9-chloroacridines to provide a range of novel acridine–isoalloxazine conjugates. The combination of these two moieties, both of biological interest, was achieved by a chromatography-free route.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.04.035