Metal-free oxidative arylphosphination of activated N-substituted-N-arylacrylamide derivatives using K2S2O8

Metal-free oxidative arylphosphination of activated N-substituted-N-arylacrylamide derivatives using K2S2O8

A novel metal-free oxidative arylphosphination of activated N-substituted-N-arylacrylamide derivatives by phosphorylation and C–H functionalization cascade process has been developed. This methodology provides an efficient way to construct a variety of phosphorus-containing oxindole moieties. [Displ...

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Veröffentlicht in:Tetrahedron 2014-03, Vol.70 (11), p.1991-1996
Hauptverfasser: Li, Ya-Min, Shen, Yuehai, Chang, Kwen-Jen, Yang, Shang-Dong
Format: Artikel
Sprache:eng
Schlagworte:
Activated
Activated alkenes
Arylphosphination
Cascades
Construction
Derivatives
Difunctionalization
Metal-free
Methodology
Oxindole
Phosphorylation
Tetrahedrons
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Zusammenfassung:A novel metal-free oxidative arylphosphination of activated N-substituted-N-arylacrylamide derivatives by phosphorylation and C–H functionalization cascade process has been developed. This methodology provides an efficient way to construct a variety of phosphorus-containing oxindole moieties. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.01.065