Pyrrolidine and iodine catalyzed domino aldol-Michael-dehydrogenative synthesis of flavones

Pyrrolidine and iodine catalyzed domino aldol-Michael-dehydrogenative synthesis of flavones

A one pot synthesis of flavones is established from 2′-hydroxyacetophenones and substituted aromatic aldehydes. The method uses domino aldol-Michael-oxidation reaction catalyzed by pyrrolidine as a base and iodine as an oxidant in dimethyl sulfoxide.

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Veröffentlicht in:Tetrahedron letters 2014-05, Vol.55 (22), p.3340-3343
Hauptverfasser: Naik, Mayuri M., Tilve, Santosh G., Kamat, Vijayendra P.
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Aldol
Dimethyl sulfoxide
Domino
Flavones
Iodine
Oxidants
Oxidizing agents
Pyrrolidine
Synthesis (chemistry)
Tetrahedrons
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Beschreibung
Zusammenfassung:A one pot synthesis of flavones is established from 2′-hydroxyacetophenones and substituted aromatic aldehydes. The method uses domino aldol-Michael-oxidation reaction catalyzed by pyrrolidine as a base and iodine as an oxidant in dimethyl sulfoxide.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.04.051