Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides

A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (78–92%) via boron esters of N-(2-hydroxyethyl) amides. A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (75–94%) via boron esters of N-(2-hydroxyethyl) am...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2010-10, Vol.51 (40), p.5313-5315
Hauptverfasser: Ilkgul, Baris, Gunes, Deniz, Sirkecioglu, Okan, Bicak, Niyazi
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (78–92%) via boron esters of N-(2-hydroxyethyl) amides. A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (75–94%) via boron esters of N-(2-hydroxyethyl) amides. The procedure involves thermolysis of the boron esters at 240–260 °C, in the presence of solid CaO as an acid scavenger and allows the preparation of oxazolines from hydroxyethyl amides of aliphatic and aromatic monocarboxylic acids.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.07.167