One-pot conversion of phenols to anilines via Smiles rearrangement

One-pot conversion of phenols to anilines via Smiles rearrangement

A convenient one-pot synthesis of phenols to anilines using 2-chloroacetamide/K2CO3/DMF system catalyzed by KI via Smiles rearrangement has been described. The synthesis of extensive amino aromatic products from phenols containing electron withdrawing group, has been performed in moderate to excelle...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2013-09, Vol.54 (38), p.5151-5154
Hauptverfasser: Xie, Yong-Sheng, Vijaykumar, B.V.D., Jang, Kiwan, Shin, Hong-Hyun, Zuo, Hua, Shin, Dong-Soo
Format: Artikel
Sprache:eng
Schlagworte:
Aniline
Conversion
One-pot synthesis
Pharmaceuticals
Phenol
Phenols
Smiles rearrangement
Synthesis
Tetrahedrons
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A convenient one-pot synthesis of phenols to anilines using 2-chloroacetamide/K2CO3/DMF system catalyzed by KI via Smiles rearrangement has been described. The synthesis of extensive amino aromatic products from phenols containing electron withdrawing group, has been performed in moderate to excellent yields to demonstrate the potentiality of this method in bio-medicinal and pharmaceutical applications.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.06.022