Synthetic studies toward biselides. Part 1: synthesis of the core carbon framework of biselides A, B, and E using Stille coupling

Synthetic studies toward biselides. Part 1: synthesis of the core carbon framework of biselides A, B, and E using Stille coupling

Biselides A and B are cytotoxic marine polyketides. We have achieved synthesis of the C-1–C-15 segment of biselides A and B by using Stille coupling and regioselective oxidative cleavage as key steps. Furthermore, we constructed the α,β-unsaturated lactone part of biselide E by using a similar strat...

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Veröffentlicht in:Tetrahedron letters 2012-03, Vol.53 (11), p.1390-1392
Hauptverfasser: Satoh, Yohsuke, Kawamura, Dai, Yamaura, Masashi, Ikeda, Yoichi, Ochiai, Yumi, Hayakawa, Ichiro, Kigoshi, Hideo
Format: Artikel
Sprache:eng
Schlagworte:
Biselides
Carbon
Cleavage
Joining
Lactones
Polyketides
Regioselective oxidative cleavage
Segments
Stille coupling
Strategy
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:Biselides A and B are cytotoxic marine polyketides. We have achieved synthesis of the C-1–C-15 segment of biselides A and B by using Stille coupling and regioselective oxidative cleavage as key steps. Furthermore, we constructed the α,β-unsaturated lactone part of biselide E by using a similar strategy.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.01.020