Regioselective synthesis of piceatannol from resveratrol: catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

Regioselective synthesis of piceatannol from resveratrol: catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

Piceatannol, a valuable biologically active stilbene derivative, was efficiently synthesized from resveratrol. Whole-cell catalysis with HpaBC monooxygenase enabled the regioselective hydroxylation of resveratrol to produce 23mM (5.2gL−1) of piceatannol.

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Veröffentlicht in:Tetrahedron letters 2014-04, Vol.55 (17), p.2853-2855
Hauptverfasser: Furuya, Toshiki, Kino, Kuniki
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Derivatives
HpaBC
Hydroxylation
Monooxygenase
Piceatannol
Stilbene
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:Piceatannol, a valuable biologically active stilbene derivative, was efficiently synthesized from resveratrol. Whole-cell catalysis with HpaBC monooxygenase enabled the regioselective hydroxylation of resveratrol to produce 23mM (5.2gL−1) of piceatannol.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.03.076