Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerate...

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Veröffentlicht in:	Tetrahedron 2012-12, Vol.68 (48), p.9949-9953
Hauptverfasser:	Huang, Yuanyuan, Fang, Xin, Lin, Xiaoxi, Li, Huaifeng, He, Weiming, Huang, Kuo-Wei, Yuan, Yaofeng, Weng, Zhiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	B derivatives Catalysis Catalysts: preparations and properties Chemistry Copper catalyst Electrophilic trifluoromethylation reaction Exact sciences and technology Functional groups General and physical chemistry Noncondensed benzenic compounds Organic chemistry Organometalloidal and organometallic compounds Preparations and properties Tetrahedrons Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry Trifluoromethylarenes
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Zusammenfassung:	An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerates a wide range of functional groups. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2012.09.083