Copper-mediated trimethylsilyl azide in amination of bromoflavonoids to synthesize unique aminoflavonoids

Copper-mediated trimethylsilyl azide in amination of bromoflavonoids to synthesize unique aminoflavonoids

Aminoflavonoids are unique antioxidants comparing to other abundant flavonoids in nature. Their syntheses and biological activities were scarcely reported. An effectively copper-mediated amination of the corresponding bromoflavonoids to synthesize a series of new aminoflavonoids is described. [Displ...

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Veröffentlicht in:Tetrahedron 2014-06, Vol.70 (23), p.3657-3664
Hauptverfasser: Shih, Tzenge-Lien, Chou, Chi-En, Liao, Wen-Yu, Hsiao, Chih-Ang
Format: Artikel
Sprache:eng
Schlagworte:
Aminoflavonoids
Antioxidants
Baker–Venkataraman rearrangement
Biological
Claisen–Schmidt reaction
Copper-mediated amination
Flavonoids
Tetrahedrons
Trimethylsilyl azide
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Zusammenfassung:Aminoflavonoids are unique antioxidants comparing to other abundant flavonoids in nature. Their syntheses and biological activities were scarcely reported. An effectively copper-mediated amination of the corresponding bromoflavonoids to synthesize a series of new aminoflavonoids is described. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.04.022