Synthesis of new trifluoromethylated indole derivatives

Synthesis of new trifluoromethylated indole derivatives

New indole trifluoromethyl derivatives have been synthesized using the reaction of indole derivatives with different 2,2,2-trifluoro-N-arylacetimidoyl chlorides in the presence of NaH as a base in acetonitrile at room temperature under an N2 atmosphere. The FT-IR, 19F NMR, 1H NMR, 13C NMR, COSY and...

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Veröffentlicht in:Tetrahedron letters 2013-08, Vol.54 (35), p.4689-4692
Hauptverfasser: Darehkordi, Ali, Rahmani, Fariba, Hashemi, Vahide
Format: Artikel
Sprache:eng
Schlagworte:
2,2,2-Trifluoro-N-arylacetimidoyl chloride
Acetonitrile
Chlorides
Derivatives
Indole
Indoles
Nuclear magnetic resonance
Spectra
Synthesis (chemistry)
Tetrahedrons
Trifluoromethylated indole
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Beschreibung
Zusammenfassung:New indole trifluoromethyl derivatives have been synthesized using the reaction of indole derivatives with different 2,2,2-trifluoro-N-arylacetimidoyl chlorides in the presence of NaH as a base in acetonitrile at room temperature under an N2 atmosphere. The FT-IR, 19F NMR, 1H NMR, 13C NMR, COSY and HMBC spectra and elemental analysis confirm the structures of the products.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.06.093