Synthesis of 4-benzyl-3-phenylbutenolide natural products

Synthesis of 4-benzyl-3-phenylbutenolide natural products

The first total synthesis of eutypoid A and a new synthesis of racemic microperfuranone and gymnoascolide A have been achieved. The key steps in our synthetic strategy involve a Suzuki coupling reaction to install the C3 aryl ring and a Mannich-type reaction for the construction of the 4-benzylbuten...

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Veröffentlicht in:Tetrahedron letters 2013-09, Vol.54 (39), p.5322-5324
Hauptverfasser: Parker, Anna N., Lock, Matthew J., Hutchison, John M.
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Chemical reactions
Construction
Eutypoid A
Gymnoascolide A
Mannich-type amino alkylation
Microperfuranone
Natural products
Strategy
Suzuki coupling
Synthesis (chemistry)
Tetrahedrons
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Beschreibung
Zusammenfassung:The first total synthesis of eutypoid A and a new synthesis of racemic microperfuranone and gymnoascolide A have been achieved. The key steps in our synthetic strategy involve a Suzuki coupling reaction to install the C3 aryl ring and a Mannich-type reaction for the construction of the 4-benzylbutenolide core.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.07.101