Efficient and convenient copper-free Pd(OAc) sub(2)/Ruphos-catalyzed Sonogashira coupling in the preparation of corfin analogues

Efficient and convenient copper-free Pd(OAc) sub(2)/Ruphos-catalyzed Sonogashira coupling in the preparation of corfin analogues

The Sonogashira coupling reaction of 3-chloro-1H-isochromen-1-one and terminal alkynes, in the presence of catalytic system-Pd(OAc) sub(2)/Ruphos, Et sub(3)N base, and tetrahydrofuran solvent under aqueous conditions, provided novel 3-(alkynyl)-1H-isochromen-1-ones in excellent yields. The methodolo...

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Veröffentlicht in:Tetrahedron letters 2015-02, Vol.56 (6), p.784-788
Hauptverfasser: Dasaradhan, Changalaraya, Kumar, Yadavalli Suneel, Prabakaran, Kamalakannan, Khan, Fazlur-Rahman Nawaz, Jeong, Euh Duck, Chung, Eun Hyuk
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Catalysis
Chemical reactions
Coupling (molecular)
Solvents
Terminals
Tetrahedrons
Tetrahydrofuran
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Zusammenfassung:The Sonogashira coupling reaction of 3-chloro-1H-isochromen-1-one and terminal alkynes, in the presence of catalytic system-Pd(OAc) sub(2)/Ruphos, Et sub(3)N base, and tetrahydrofuran solvent under aqueous conditions, provided novel 3-(alkynyl)-1H-isochromen-1-ones in excellent yields. The methodology has also been extended toward natural isochromen-1-ones-corfin analogues.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2014.12.059