A three-component, intramolecular Ugi reaction toward unique indoloketopiperazines

A three-component, intramolecular Ugi reaction toward unique indoloketopiperazines

2-(3-Chloro-2-formyl-1H-indol-1-yl) acetic acid, as a bifunctional formyl-acid, is prepared in three steps. This compound undergoes a one-pot, four-center, three-component Ugi reaction with primary amines and alkyl isocyanides. A series of novel substituted indoloketopiperazine derivatives are obtai...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2012-06, Vol.53 (26), p.3353-3356
Hauptverfasser: Ghandi, Mehdi, Zarezadeh, Nahid, Taheri, Abuzar
Format: Artikel
Sprache:eng
Schlagworte:
Acetic acid
Amines
Derivatives
Indoloketopiperazines
Isocyanides
Tetrahedrons
Ugi reactions
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:2-(3-Chloro-2-formyl-1H-indol-1-yl) acetic acid, as a bifunctional formyl-acid, is prepared in three steps. This compound undergoes a one-pot, four-center, three-component Ugi reaction with primary amines and alkyl isocyanides. A series of novel substituted indoloketopiperazine derivatives are obtained in moderate to high yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.04.090