Andirolides H–P from the flower of andiroba (Carapa guianensis, Meliaceae)

Three new gedunins, an andirobin, three mexicanolides, and two phragmalin-type limonoids named andirolides H (1), I (2), J (3), K (4), L (5), M (6), N (7), O (8), and P (9) were isolated from an oil of the flower of Carapa guianensis Aublet (Meliaceae). Their structures including the absolute config...

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Veröffentlicht in:	Tetrahedron 2012-05, Vol.68 (18), p.3669-3677
Hauptverfasser:	Tanaka, Yuji, Sakamoto, Asami, Inoue, Takanobu, Yamada, Takeshi, Kikuchi, Takashi, Kajimoto, Tetsuya, Muraoka, Osamu, Sato, Akira, Wataya, Yusuke, Kim, Hye-Sook, Tanaka, Reiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Carapa guianensis Chemistry Dichroism Exact sciences and technology Flowers Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives In vitro testing Limonoids Medical sciences Meliaceae Nuclear magnetic resonance Organic chemistry Pharmacology. Drug treatments Plasmodium falciparum Preparations and properties Spectra Steroids Terpenoids Tetrahedrons
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Zusammenfassung:	Three new gedunins, an andirobin, three mexicanolides, and two phragmalin-type limonoids named andirolides H (1), I (2), J (3), K (4), L (5), M (6), N (7), O (8), and P (9) were isolated from an oil of the flower of Carapa guianensis Aublet (Meliaceae). Their structures including the absolute configurations were determined by means of the NMR and CD spectra as well as FABMS. Andirolide H (1) showed antimalarial activity against Plasmodium falciparum in vitro. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2011.12.076