Highly enantioselective conjugate addition of nitroalkanes to enones catalyzed by cinchona alkaloid derived primary amine

A cinchona alkaloid derived primary amine catalyzed conjugate addition of nitroalkanes to enones is described. The process affords the Michael adducts in good yield and with up to 99% ee for both acyclic and cyclic enones.

Bibliographische Detailangaben

Veröffentlicht in:	Tetrahedron letters 2013-07, Vol.54 (29), p.3791-3793
Hauptverfasser:	Liu, Wenjing, Mei, Desheng, Wang, Wei, Duan, Wenhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Alkaloids Amines Asymmetric conjugate addition Chiral primary amine catalysis Cinchona alkaloids Conjugates Enones Nitroalkanes Tetrahedrons
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