Highly enantioselective conjugate addition of nitroalkanes to enones catalyzed by cinchona alkaloid derived primary amine

Highly enantioselective conjugate addition of nitroalkanes to enones catalyzed by cinchona alkaloid derived primary amine

A cinchona alkaloid derived primary amine catalyzed conjugate addition of nitroalkanes to enones is described. The process affords the Michael adducts in good yield and with up to 99% ee for both acyclic and cyclic enones.

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Veröffentlicht in:Tetrahedron letters 2013-07, Vol.54 (29), p.3791-3793
Hauptverfasser: Liu, Wenjing, Mei, Desheng, Wang, Wei, Duan, Wenhu
Format: Artikel
Sprache:eng
Schlagworte:
Adducts
Alkaloids
Amines
Asymmetric conjugate addition
Chiral primary amine catalysis
Cinchona alkaloids
Conjugates
Enones
Nitroalkanes
Tetrahedrons
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Beschreibung
Zusammenfassung:A cinchona alkaloid derived primary amine catalyzed conjugate addition of nitroalkanes to enones is described. The process affords the Michael adducts in good yield and with up to 99% ee for both acyclic and cyclic enones.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.05.019