Genomic salmon testes DNA as a catalyst for Michael reactions in water

The DNA molecule, recognized as the carrier of genetic information in vivo, can function as an efficient organocatalyst for Michael additions of 1,3-dicarbonyl compounds to activated alkenes in aqueous media. The procedure described here is environmentally benign and offers several advantages in ter...

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Veröffentlicht in:	Tetrahedron 2012-04, Vol.68 (14), p.3086-3091
Hauptverfasser:	De Rosa, Margherita, Di Marino, Sara, D’Ursi, Anna Maria, Strianese, Maria, Soriente, Annunziata
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Alkenes Analytical, structural and metabolic biochemistry Biological and medical sciences Biomedical materials Carriers Catalysis Catalysts Catalysts: preparations and properties Chemistry Deoxyribonucleic acid DNA Dna, deoxyribonucleoproteins Exact sciences and technology Fluorescence Fluorescence spectrometry Fundamental and applied biological sciences. Psychology General and physical chemistry Genetics Michael addition Nucleic acids Organic chemistry Preparations and properties Salmonidae Surgical implants Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry Water
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The DNA molecule, recognized as the carrier of genetic information in vivo, can function as an efficient organocatalyst for Michael additions of 1,3-dicarbonyl compounds to activated alkenes in aqueous media. The procedure described here is environmentally benign and offers several advantages in terms of simplicity, generality and efficiency. We have used fluorescence spectroscopy to evaluate the catalytic activity of a molecule of DNA. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2012.02.007