Synthesis and photophysical properties of 8-arylbutadienyl 2′-deoxyguanosines

Synthesis and photophysical properties of 8-arylbutadienyl 2′-deoxyguanosines

We have developed novel push–pull-type 8-arylbutadienyl 2′-deoxyguanosine derivatives, ABG ( 1a) and CBG ( 1b). These nucleosides exhibit strong solvent polarity dependent fluorescence emission at long wavelength (ca. 490–550 nm). These environmentally sensitive fluorescent deoxyguanosines are power...

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Veröffentlicht in:Tetrahedron letters 2011-01, Vol.52 (4), p.491-494
Hauptverfasser: Saito, Yoshio, Koda, Makio, Shinohara, Yuta, Saito, Isao
Format: Artikel
Sprache:eng
Schlagworte:
Derivatives
Emission
Fluorescence
Nucleosides
Polarity
Solvents
Tetrahedrons
Wavelengths
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Zusammenfassung:We have developed novel push–pull-type 8-arylbutadienyl 2′-deoxyguanosine derivatives, ABG ( 1a) and CBG ( 1b). These nucleosides exhibit strong solvent polarity dependent fluorescence emission at long wavelength (ca. 490–550 nm). These environmentally sensitive fluorescent deoxyguanosines are powerful tools for structural studies of nucleic acids and also in molecular diagnostics.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.11.053