One-step method for synthesis of 2,4-disubstituted quinazoline 3-oxides by reaction of a 2-aminoaryl ketone with a hydroxamic acid using Zn(OTf) sub(2) as the catalyst

One-step method for synthesis of 2,4-disubstituted quinazoline 3-oxides by reaction of a 2-aminoaryl ketone with a hydroxamic acid using Zn(OTf) sub(2) as the catalyst

A simple and efficient method for the preparation of 2,4-disubstituted quinazoline 3-oxides by reaction of a hydroxamic acid with 2-aminoaryl ketones using zinc(II) triflate as the catalyst is described.

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Veröffentlicht in:Tetrahedron letters 2014-03, Vol.55 (12), p.1979-1982
Hauptverfasser: Madabhushi, Sridhar, Mallu, Kishore Kumar Reddy, Jillella, Raveendra, Kurva, Srinivas, Singh, Rajpal
Format: Artikel
Sprache:eng
Schlagworte:
Catalysts
Ketones
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:A simple and efficient method for the preparation of 2,4-disubstituted quinazoline 3-oxides by reaction of a hydroxamic acid with 2-aminoaryl ketones using zinc(II) triflate as the catalyst is described.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2014.01.150