A Facile Chromatographic Method for Purification of Pinacol Boronic Esters

A Facile Chromatographic Method for Purification of Pinacol Boronic Esters

A facile chromatographic method for purification of pinacol boronic esters has been developed. Impregnation of silica gel with boric acid was effective both for thin layer chromatography (TLC) and for flash column chromatography. Purification of a series of pinacol boronic esters was successful by s...

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Veröffentlicht in:Chemistry letters 2012-09, Vol.41 (9), p.972-973
Hauptverfasser: Hitosugi, Shunpei, Tanimoto, Daiki, Nakanishi, Waka, Isobe, Hiroyuki
Format: Artikel
Sprache:eng
Schlagworte:
Boric acids
Chromatography
Column chromatography
Esters
Purification
Retarding
Silica gel
Thin layer chromatography
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Zusammenfassung:A facile chromatographic method for purification of pinacol boronic esters has been developed. Impregnation of silica gel with boric acid was effective both for thin layer chromatography (TLC) and for flash column chromatography. Purification of a series of pinacol boronic esters was successful by suppressing loss of the compounds due to over-adsorption.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2012.972