Voacalgines A–E, new indole alkaloids from Voacanga grandifolia

Voacalgines A–E, new indole alkaloids from Voacanga grandifolia

Five new indole alkaloids, voacalgines A–E (1–5) consisting of a C-mavacurine type of skeleton with 2,3-dihydroxybenzoate moiety, a macroline-type of skeleton, or a macroline-type of skeleton with C6 unit, were isolated from the bark of Voacanga grandifolia. Their relative structures were determined...

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Veröffentlicht in:Tetrahedron 2013-12, Vol.69 (51), p.10869-10875
Hauptverfasser: Hirasawa, Yusuke, Arai, Hiroko, Rahman, Abdul, Kusumawati, Idha, Zaini, Noor Cholies, Shirota, Osamu, Morita, Hiroshi
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
Bark
Cytotoxicity
Indole alkaloid
Indoles
Nuclear magnetic resonance
Tetrahedrons
Voacalgine A
Voacanga grandifolia
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Zusammenfassung:Five new indole alkaloids, voacalgines A–E (1–5) consisting of a C-mavacurine type of skeleton with 2,3-dihydroxybenzoate moiety, a macroline-type of skeleton, or a macroline-type of skeleton with C6 unit, were isolated from the bark of Voacanga grandifolia. Their relative structures were determined by means of NMR data. Voacalgine A showed moderate cell growth inhibitory activities against HL-60 and HCT116 cells. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2013.10.097