Regiospecific strategies for the synthesis of novel dihydropyrimidinones and pyrimidopyridazines catalyzed by molybdate sulfuric acid

Regiospecific strategies for the synthesis of novel dihydropyrimidinones and pyrimidopyridazines catalyzed by molybdate sulfuric acid

The one-pot reactions of aryl glyoxals with acetylacetone and urea using molybdate sulfuric acid (5mol%) lead to the novel functionalized 5-acetyl-4-(aryloyl)-3,4-dihydropyrimidinones, which readily undergo the Knorr condensation with hydrazines to produce new pyrimido[4,5-d]pyridazines. The present...

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Veröffentlicht in:Tetrahedron letters 2014-06, Vol.55 (26), p.3581-3584
Hauptverfasser: Karami, Bahador, Khodabakhshi, Saeed, Akrami, Sedigheh, Farahi, Mahnaz
Format: Artikel
Sprache:eng
Schlagworte:
Acetylacetone
Aryl glyoxal
Condensing
Hydrazine
Hydrazines
Molybdates
Pyrimido[4,5-d]pyridazines
Strategy
Sulfuric acid
Tetrahedrons
Ureas
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Zusammenfassung:The one-pot reactions of aryl glyoxals with acetylacetone and urea using molybdate sulfuric acid (5mol%) lead to the novel functionalized 5-acetyl-4-(aryloyl)-3,4-dihydropyrimidinones, which readily undergo the Knorr condensation with hydrazines to produce new pyrimido[4,5-d]pyridazines. The present strategies are in accordance with green chemistry principles through the use of a safe and recyclable catalyst under solvent-free conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.02.025