Amphirionin-5, a novel linear polyketide from a cultured marine dinoflagellate Amphidinium species with a potent cell proliferation-promoting activity

Amphirionin-5, a novel linear polyketide from a cultured marine dinoflagellate Amphidinium species with a potent cell proliferation-promoting activity

A novel linear polyketide, amphirionin-5 (1), has been isolated from the cultivated algal cells of the benthic dinoflagellate Amphidinium sp. (strain KCA09053), and the structure was elucidated on the basis of detailed analyses of 1D and 2D NMR data. Amphirionin-5 (1) resulted in a 282% increase in...

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Veröffentlicht in:Tetrahedron letters 2014-06, Vol.55 (24), p.3491-3494
Hauptverfasser: Akakabe, Mai, Kumagai, Keiko, Tsuda, Masayuki, Konishi, Yuko, Tominaga, Akira, Tsuda, Masashi, Fukushi, Eri, Kawabata, Jun
Format: Artikel
Sprache:eng
Schlagworte:
Algae
Amphidinium
Biocompatibility
Biomedical materials
Cell-proliferation promoting activity
Dinoflagellate
Dinoflagellates
Marine
Polyketide
Strain
Tetrahedrons
Two dimensional
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Zusammenfassung:A novel linear polyketide, amphirionin-5 (1), has been isolated from the cultivated algal cells of the benthic dinoflagellate Amphidinium sp. (strain KCA09053), and the structure was elucidated on the basis of detailed analyses of 1D and 2D NMR data. Amphirionin-5 (1) resulted in a 282% increase in the proliferation of murine bone-marrow derived stromal ST-2 cells and 320% increase in the proliferation of murine osteoblastic MC3T3-E1 cells.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.04.086