Continuous flow whole cell bioreduction of fluorinated acetophenone

Continuous flow whole cell bioreduction of fluorinated acetophenone

Several microorganism strains were used to reduce 2,2,2-trifluoroacetophenone (1) and 4′-Br-2,2,2-trifluoroacetophenone (3). Immobilized cells of Geotrichum candidum in calcium alginate led to conversion and enantiomeric excess higher than 99%. By using immobilized G. candidum cells under continuous...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron 2014-05, Vol.70 (20), p.3239-3242
Hauptverfasser: de Oliveira Lopes, Raquel, Ribeiro, Joyce Benzaquem, Silva de Miranda, Amanda, Vieira da Silva, Gabriela Veloso, Miranda, Leandro S.M., Ramos Leal, Ivana Corrêa, Mendonça Alves de Souza, Rodrigo Octavio
Format: Artikel
Sprache:eng
Schlagworte:
Bioreduction
Calcium alginate
Chiral trifluoromethyl alcohols
Continuous flow
Conversion
Fluorination
Geotrichum candidum
Microorganisms
Strain
Tetrahedrons
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Several microorganism strains were used to reduce 2,2,2-trifluoroacetophenone (1) and 4′-Br-2,2,2-trifluoroacetophenone (3). Immobilized cells of Geotrichum candidum in calcium alginate led to conversion and enantiomeric excess higher than 99%. By using immobilized G. candidum cells under continuous flow conditions, the same conversion and enantiomeric excess were achieved in 90 min of residence time. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2013.12.036