Catalytic asymmetric bromolactonization reactions using (DHQD)2PHAL-benzoic acid combinations

Catalytic asymmetric bromolactonization reactions using (DHQD)2PHAL-benzoic acid combinations

Catalytic (DHQD)2PHAL as modified by added benzoic acid, is an off-the-shelf catalyst-additive combination for effecting catalytic asymmetric bromolactonization reactions. This combination delivers bromolactones with asymmetric induction at a comparable level to bespoke catalysts previously optimize...

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Veröffentlicht in:Tetrahedron letters 2013-12, Vol.54 (51), p.7004-7008
Hauptverfasser: Armstrong, Alan, Braddock, D. Christopher, Jones, Alexander X., Clark, Stacy
Format: Artikel
Sprache:eng
Schlagworte:
Additive effects
Asymmetric organocatalysis
Asymmetry
Benzoic acid
Bromolactonization reaction
Carboxylic acids
Catalysis
Catalysts
Cinchona alkaloid
Tetrahedrons
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Beschreibung
Zusammenfassung:Catalytic (DHQD)2PHAL as modified by added benzoic acid, is an off-the-shelf catalyst-additive combination for effecting catalytic asymmetric bromolactonization reactions. This combination delivers bromolactones with asymmetric induction at a comparable level to bespoke catalysts previously optimized for particular substrate classes.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.10.043