Studies Towards the Synthesis of Medermycin via Dötz Benzannulation

The C‐arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O‐carbamate directed ipso bromination and nitrile substitution in good over...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2015-01, Vol.27 (1), p.18-22
Hauptverfasser:	Qu, Chunrong, Tang, Erqing, Loeppky, Richard, Deng, Zixin, Pulley, Shon R., Hong, Xuechuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Bromination C-arylglycoside Carbenes Chirality Chromium Dötz benzannulation Fischer carbene complex ipso bromination Molecular Structure Naphthoquinones - chemical synthesis Naphthoquinones - chemistry Nitriles Precursors Stereoisomerism Streptomyces sp Synthesis (chemistry)
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creator	Qu, Chunrong Tang, Erqing Loeppky, Richard Deng, Zixin Pulley, Shon R. Hong, Xuechuan
description	The C‐arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O‐carbamate directed ipso bromination and nitrile substitution in good overall yields. Chirality 27:18–22, 2015. © 2014 Wiley Periodicals, Inc.
doi_str_mv	10.1002/chir.22383
format	Article
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subjects	Alkynes Bromination C-arylglycoside Carbenes Chirality Chromium Dötz benzannulation Fischer carbene complex ipso bromination Molecular Structure Naphthoquinones - chemical synthesis Naphthoquinones - chemistry Nitriles Precursors Stereoisomerism Streptomyces sp Synthesis (chemistry)
title	Studies Towards the Synthesis of Medermycin via Dötz Benzannulation
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