Studies Towards the Synthesis of Medermycin via Dötz Benzannulation

Studies Towards the Synthesis of Medermycin via Dötz Benzannulation

The C‐arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O‐carbamate directed ipso bromination and nitrile substitution in good over...

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Veröffentlicht in:Chirality (New York, N.Y.) N.Y.), 2015-01, Vol.27 (1), p.18-22
Hauptverfasser: Qu, Chunrong, Tang, Erqing, Loeppky, Richard, Deng, Zixin, Pulley, Shon R., Hong, Xuechuan
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Bromination
C-arylglycoside
Carbenes
Chirality
Chromium
Dötz benzannulation
Fischer carbene complex
ipso bromination
Molecular Structure
Naphthoquinones - chemical synthesis
Naphthoquinones - chemistry
Nitriles
Precursors
Stereoisomerism
Streptomyces sp
Synthesis (chemistry)
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Zusammenfassung:The C‐arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O‐carbamate directed ipso bromination and nitrile substitution in good overall yields. Chirality 27:18–22, 2015. © 2014 Wiley Periodicals, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.22383