Total synthesis of agomelatine via Friedel–Crafts acylation followed by Willgerodt–Kindler reaction
Total synthesis of antidepressant drug, agomelatine is reported. Regio selective Friedel–Crafts acylation followed by Willgerodt–Kindler reactions is used as the key steps for the synthesis of agomelatine.
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| Veröffentlicht in: | Tetrahedron letters 2014-07, Vol.55 (29), p.3885-3887 |
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| container_title | Tetrahedron letters |
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| creator | Vujjini, Satish Kumar Datla, V.R. Krishnam Raju Badarla, Krishna Rao Vetukuri, V.N.K.V. Prasada Raju Bandichhor, Rakeshwar Kagga, Mukkanti Cherukupally, Praveen |
| description | Total synthesis of antidepressant drug, agomelatine is reported. Regio selective Friedel–Crafts acylation followed by Willgerodt–Kindler reactions is used as the key steps for the synthesis of agomelatine. |
| doi_str_mv | 10.1016/j.tetlet.2014.03.106 |
| format | Article |
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| ispartof | Tetrahedron letters, 2014-07, Vol.55 (29), p.3885-3887 |
| issn | 0040-4039 1873-3581 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Acylation Agomelatine Antidepressant drug Antidepressants Drugs Friedel–Crafts acylation Regio selectivity Synthesis (chemistry) Tetrahedrons Willgerodt–Kindler reaction |
| title | Total synthesis of agomelatine via Friedel–Crafts acylation followed by Willgerodt–Kindler reaction |
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