Total synthesis of agomelatine via Friedel–Crafts acylation followed by Willgerodt–Kindler reaction

Total synthesis of agomelatine via Friedel–Crafts acylation followed by Willgerodt–Kindler reaction

Total synthesis of antidepressant drug, agomelatine is reported. Regio selective Friedel–Crafts acylation followed by Willgerodt–Kindler reactions is used as the key steps for the synthesis of agomelatine.

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Veröffentlicht in:Tetrahedron letters 2014-07, Vol.55 (29), p.3885-3887
Hauptverfasser: Vujjini, Satish Kumar, Datla, V.R. Krishnam Raju, Badarla, Krishna Rao, Vetukuri, V.N.K.V. Prasada Raju, Bandichhor, Rakeshwar, Kagga, Mukkanti, Cherukupally, Praveen
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Agomelatine
Antidepressant drug
Antidepressants
Drugs
Friedel–Crafts acylation
Regio selectivity
Synthesis (chemistry)
Tetrahedrons
Willgerodt–Kindler reaction
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Beschreibung
Zusammenfassung:Total synthesis of antidepressant drug, agomelatine is reported. Regio selective Friedel–Crafts acylation followed by Willgerodt–Kindler reactions is used as the key steps for the synthesis of agomelatine.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.03.106