Basic ionic liquid promoted heterocyclization to access fused imidazopyridines

Basic ionic liquid promoted heterocyclization to access fused imidazopyridines

A single step access to fused imidazopyridine involving [bmIm]OH promoted click cyclocondensation of N-methylisatin with 2-aminopyridine has been achieved. The title heterocyclic scaffolds were obtained in excellent yield with high purity. [bmIm]OH was found to be more attractive as it plays the rol...

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Veröffentlicht in:Tetrahedron letters 2013-09, Vol.54 (37), p.5083-5086
Hauptverfasser: Siddiqui, I.R., Shireen, Shamim, Shayna, Waseem, Malik Abdul, Abumhdi, Afaf A.H., Srivastava, Arjita, Srivastava, Anjali
Format: Artikel
Sprache:eng
Schlagworte:
Catalysts
Heterocyclization
Imidazopyridine
Ionic liquid
Ionic liquids
Mild reaction conditions
Purity
Room temperature
Scaffolds
Solvents
Tetrahedrons
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Beschreibung
Zusammenfassung:A single step access to fused imidazopyridine involving [bmIm]OH promoted click cyclocondensation of N-methylisatin with 2-aminopyridine has been achieved. The title heterocyclic scaffolds were obtained in excellent yield with high purity. [bmIm]OH was found to be more attractive as it plays the role of solvent, base, and catalyst.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.07.054