Domino synthesis of 1,3-diynes from 1,1-dibromoalkenes: a Pd-catalyzed copper-free coupling method

Domino synthesis of 1,3-diynes from 1,1-dibromoalkenes: a Pd-catalyzed copper-free coupling method

[Display omitted] Pd-catalyzed domino synthesis of 1,3-diynes was accomplished using 1,1-dibomoalkenes under copper-free coupling conditions. This domino procedure involves base mediated in situ generation of 1-bromoalkyne and its subsequent coupling to give 1,3-diyne. The optimized copper-free coup...

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Veröffentlicht in:Tetrahedron letters 2014-06, Vol.55 (25), p.3529-3533
Hauptverfasser: Rao, Maddali L.N., Dasgupta, Priyabrata, Ramakrishna, Boddu S., Murty, Venneti N.
Format: Artikel
Sprache:eng
Schlagworte:
1,1-Dibromoalkenes
1,3-Diynes
Copper-free
Coupling (molecular)
Couplings
Domino
Palladium
Pd-catalyzed
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:[Display omitted] Pd-catalyzed domino synthesis of 1,3-diynes was accomplished using 1,1-dibomoalkenes under copper-free coupling conditions. This domino procedure involves base mediated in situ generation of 1-bromoalkyne and its subsequent coupling to give 1,3-diyne. The optimized copper-free coupling method afforded good to high yields of symmetrical 1,3-diynes in a one-pot operation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.04.092