Useful four-carbon synthons en route to monastrol analogs

Useful four-carbon synthons en route to monastrol analogs

A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI...

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Veröffentlicht in:Tetrahedron 2015-01, Vol.71 (1), p.139-146
Hauptverfasser: Abdou, Amr M., Botros, S., Hassan, Rasha A., Kamel, Mona M., Taber, Douglass F., Taher, Azza T.
Format: Artikel
Sprache:eng
Schlagworte:
Analogs
Anti-cancer activity
Anticancer properties
Biginelli
Biotechnology
Crystal structure
Ester exchange
Esters
Monastrol analogs
Panels
Tetrahedrons
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Zusammenfassung:A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI 60 cell line panel. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.11.022