One-pot synthesis of phthalides via regioselective intramolecular cyclization from ortho-alkynylbenzaldehydes

One-pot synthesis of phthalides via regioselective intramolecular cyclization from ortho-alkynylbenzaldehydes

A one-pot synthesis of phthalides via an intramolecular 5- exo-dig cyclization of ortho-alkynylbenzaldehydes under mild NaClO 2 oxidation conditions is described. A one-pot synthesis of phthalides via an intramolecular 5- exo-dig cyclization of ortho-alkynylbenzaldehydes under mild NaClO 2 oxidation...

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Veröffentlicht in:Tetrahedron letters 2010-11, Vol.51 (45), p.5937-5939
Hauptverfasser: Li, Jim, Chin, Elbert, Lui, Alfred S., Chen, Lijing
Format: Artikel
Sprache:eng
Schlagworte:
Oxidation
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:A one-pot synthesis of phthalides via an intramolecular 5- exo-dig cyclization of ortho-alkynylbenzaldehydes under mild NaClO 2 oxidation conditions is described. A one-pot synthesis of phthalides via an intramolecular 5- exo-dig cyclization of ortho-alkynylbenzaldehydes under mild NaClO 2 oxidation conditions is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.09.023