Complementary α-alkylation approaches for a sterically hindered spiro[pyrazolopyranpiperidine]ketone

Complementary α-alkylation approaches for a sterically hindered spiro[pyrazolopyranpiperidine]ketone

Complementary α-alkylation methods are used to derivatize a sterically hindered spiro[pyrazolopyranpiperidine]ketone. More specifically, enolate alkylations in the presence of DMPU and aldol condensations are employed to deliver these compounds.

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2012-05, Vol.53 (20), p.2543-2547
Hauptverfasser: Limberakis, Chris, Li, Jianke, Balan, Gayatri, Griffith, David A., Kung, Daniel W., Rose, Colin, Vrieze, Derek
Format: Artikel
Sprache:eng
Schlagworte:
1,4-Addition
Aldehydes
Aldol condensation
Alkylation
Condensing
DMPU
Enolate alkylation
Spiro[pyrazolopyranpiperidine]ketone
Tetrahedrons
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Beschreibung
Zusammenfassung:Complementary α-alkylation methods are used to derivatize a sterically hindered spiro[pyrazolopyranpiperidine]ketone. More specifically, enolate alkylations in the presence of DMPU and aldol condensations are employed to deliver these compounds.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.03.030