Synthesis of amide libraries with immobilized HOBt

Highly reactive N-acylating solid-phase reagents based on macroporous polystyrene-bound 1-hydroxybenzotriazole (P-HOBt) and silica-bound 1-hydroxybenzotriazole (Si-HOBt) were prepared and compared for reactivity by synthesis of small combinatorial libraries of acetamides and benzamides.

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Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2011-05, Vol.52 (21), p.2722-2724
Hauptverfasser:	Vokkaliga, Smitha, Jeong, Jeannie, LaCourse, William R., Kalivretenos, Aristotle
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Amide library Amides Benzamide Chemical reactivity Chemistry Combinatorial analysis Combinatorial library Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Libraries Organic chemistry Polymer-bound hydroxybenzotriazole Preparations and properties Reactivity and mechanisms Solid-phase synthesis Synthesis (chemistry) Tetrahedrons
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Beschreibung
Zusammenfassung:	Highly reactive N-acylating solid-phase reagents based on macroporous polystyrene-bound 1-hydroxybenzotriazole (P-HOBt) and silica-bound 1-hydroxybenzotriazole (Si-HOBt) were prepared and compared for reactivity by synthesis of small combinatorial libraries of acetamides and benzamides.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.03.097