Synthesis of isoindolinones via inverse-electron demand Diels–Alder cycloadditions
A new synthetic method has been developed for the synthesis of 2,4,5-substituted isoindolinones by means of intramolecular inverse-electron demand Diels–Alder cycloaddition reactions of substituted pyridazines. By taking advantage of the inherent reactivity of an intermediate chloropyridazine, a div...
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| Veröffentlicht in: | Tetrahedron letters 2014-04, Vol.55 (14), p.2286-2289 |
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| container_title | Tetrahedron letters |
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| creator | Huntley, Raymond J. Gurram, Mahender Walker, Joel R. Jenkins, David M. Robé, Emmanuel J. Ahmed, Feryan |
| description | A new synthetic method has been developed for the synthesis of 2,4,5-substituted isoindolinones by means of intramolecular inverse-electron demand Diels–Alder cycloaddition reactions of substituted pyridazines. By taking advantage of the inherent reactivity of an intermediate chloropyridazine, a diverse set of analogues were prepared from common reagents and intermediates. |
| doi_str_mv | 10.1016/j.tetlet.2014.02.093 |
| format | Article |
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| ispartof | Tetrahedron letters, 2014-04, Vol.55 (14), p.2286-2289 |
| issn | 0040-4039 1873-3581 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Chloropyridazines Cycloaddition Demand Diels–Alder cycloadditions Inverse-electron demand cyclizations Isoindolinones Phthalimidine Pyridazines Synthesis (chemistry) Tetrahedrons |
| title | Synthesis of isoindolinones via inverse-electron demand Diels–Alder cycloadditions |
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