Synthesis of isoindolinones via inverse-electron demand Diels–Alder cycloadditions

Synthesis of isoindolinones via inverse-electron demand Diels–Alder cycloadditions

A new synthetic method has been developed for the synthesis of 2,4,5-substituted isoindolinones by means of intramolecular inverse-electron demand Diels–Alder cycloaddition reactions of substituted pyridazines. By taking advantage of the inherent reactivity of an intermediate chloropyridazine, a div...

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Veröffentlicht in:Tetrahedron letters 2014-04, Vol.55 (14), p.2286-2289
Hauptverfasser: Huntley, Raymond J., Gurram, Mahender, Walker, Joel R., Jenkins, David M., Robé, Emmanuel J., Ahmed, Feryan
Format: Artikel
Sprache:eng
Schlagworte:
Chloropyridazines
Cycloaddition
Demand
Diels–Alder cycloadditions
Inverse-electron demand cyclizations
Isoindolinones
Phthalimidine
Pyridazines
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:A new synthetic method has been developed for the synthesis of 2,4,5-substituted isoindolinones by means of intramolecular inverse-electron demand Diels–Alder cycloaddition reactions of substituted pyridazines. By taking advantage of the inherent reactivity of an intermediate chloropyridazine, a diverse set of analogues were prepared from common reagents and intermediates.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.02.093