2,5,7-Trisubstituted benzo[ b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process

2,5,7-Trisubstituted benzo[ b]furans are prepared from 2-bromo- and 2-chloro-6-iodo-4-substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process. A straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[ b]furans from 2-bromo-...

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Veröffentlicht in:Tetrahedron letters 2011-10, Vol.52 (40), p.5149-5152
Hauptverfasser: Arcadi, Antonio, Blesi, Federico, Cacchi, Sandro, Fabrizi, Giancarlo, Goggiamani, Antonella
Format: Artikel
Sprache:eng
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Zusammenfassung:2,5,7-Trisubstituted benzo[ b]furans are prepared from 2-bromo- and 2-chloro-6-iodo-4-substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process. A straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[ b]furans from 2-bromo- and 2-chloro-6-iodo-4-substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process is described. Functionalization at the C(7) position is carried out by Suzuki–Miyaura cross-coupling and C–N bond forming reactions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.07.122