2,5,7-Trisubstituted benzo[ b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process
2,5,7-Trisubstituted benzo[ b]furans are prepared from 2-bromo- and 2-chloro-6-iodo-4-substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process. A straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[ b]furans from 2-bromo-...
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Veröffentlicht in: | Tetrahedron letters 2011-10, Vol.52 (40), p.5149-5152 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | 2,5,7-Trisubstituted benzo[
b]furans are prepared from 2-bromo- and 2-chloro-6-iodo-4-substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process.
A straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[
b]furans from 2-bromo- and 2-chloro-6-iodo-4-substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process is described. Functionalization at the C(7) position is carried out by Suzuki–Miyaura cross-coupling and C–N bond forming reactions. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2011.07.122 |