Sequential alkylation/gold-catalyzed annulation reactions of anilines with propargylic bromide derivatives

Preliminary results of sequential alkylation/gold-catalyzed annulation reactions of anilines with propargylic bromide derivatives to provide quinoline scaffolds are described. The efficiency of NaAuCl 4·2H 2O in the sequential procedure was investigated and compared with different transition metal s...

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Veröffentlicht in:	Tetrahedron letters 2011-10, Vol.52 (40), p.5145-5148
Hauptverfasser:	Alfonsi, Maria, Arcadi, Antonio, Chiarini, Marco, Marinelli, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Aniline Bromides Chemical reactions Chemistry Derivatives Exact sciences and technology Gold catalysis Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Intramolecular hydroarylation N-Propargylation Noncondensed benzenic compounds Organic chemistry Preparations and properties Quinoline Quinolines Sequential reactions Transition metals
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Zusammenfassung:	Preliminary results of sequential alkylation/gold-catalyzed annulation reactions of anilines with propargylic bromide derivatives to provide quinoline scaffolds are described. The efficiency of NaAuCl 4·2H 2O in the sequential procedure was investigated and compared with different transition metal salts and Au(I) complexes. Selectivity of the reaction of aniline derivatives with propargylic bromides has also been investigated.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.07.115